Immunoway/ETC-159/10mg 50mg 100mg/MC0959
市场价：
¥6000.00
美元价：
3000.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ETC-159
- Catalog No.：MC0959
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 1638250-96-0
- MolecularFormula：
- C19H17N7O3
- Purity：
- >98%
- Target：
- Wnt
- IC50：
- IC50: 2.9 nM (β-catenin)[1]
- In Vitro：
- ETC-159 blocks the secretion and activity of all Wnts. ETC-159 has robust activity in multiple cancer models driven by high Wnt signaling. ETC-159 is highly efficacious in molecularly defined colorectal cancers (CRCs) with R-spondin translocations[1]
- In Vivo：
- ETC-159 inhibits mouse PORCN with an IC50 of 18.1 nM, whereas the IC50 for Xenopus Porcn is approximately four fold higher (70 nM). ETC-159 is remarkably effective in treating RSPO-translocation bearing colorectal cancer (CRC) patient-derived xenografts. ETC-159 exhibits good oral pharmacokinetics in mice allowing preclinical evaluation via oral administration. After a single oral dose of 5 mg/kg, ETC-159 is rapidly absorbed into the blood with a Tmax of ~0.5 h and oral bioavailability of 100%[1].
- Fields：
- ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits _beta_-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
- Specificity：
- Target: Wnt . Fields: ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits _beta_-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
- Source：
- Rabbit
- Dilution：
- IC50: 2.9 nM (β-catenin)[1]
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- ETC-159，ETC 159，ETC159，ETC 1922159，ETC-1922159，ETC1922159
- MolecularWeight(Da)：
- 391.38
- References：
- [1]. Madan B, et al. Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene. 2015 Aug 10. doi: 10.1038/onc.2015.280.
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品牌介绍
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品牌分类
\Elisa试剂盒\
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