Immunoway/Apitolisib（GDC-0980）/10mg 50mg 100mg/MC0156
市场价：
¥5200.00
美元价：
2600.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Apitolisib(GDC-0980)
- Catalog No.：MC0156
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 1032754-93-0
- MolecularFormula：
- C23H30N8O3S
- Purity：
- >98%
- Target：
- PI3K
- IC50：
- IC50: 5 nM (PI3Kα), 27 nM (PI3Kβ), 7 nM (PI3Kδ), 14 nM (PI3Kγ)
- In Vitro：
- GDC-0980 is remarkably selective for several other members of the closely related PIKK family kinases: C2alpha IC50=1300 nM; C2beta IC50=7 94 nM; VPS34 IC50=2000 nM; PI4Kalpha >10 μM; PI4Kbeta >10 μM; DNA-PK Kiapp=623 nM, respectively[1]. A recent study shows that GDC-0980 reduces cancer cell viability by inhibiting cell-cycle procession and inducing apoptosis with most potency in prostate (IC50 < 200="" nm="" 50%),=""><500 nm="" 100%),="" breast=""><200 nm="" 37%,=""><500 nm="" 78%)="" and="" nsclc="" lines=""><200 nm="" 29%,=""><500 nm="" 88%)="" and="" less="" potency="" in="" pancreatic=""><200 nm="" 13%,=""><500 nm="" 67%)="" and="" melanoma="" cell="" lines=""><200 nm="" 0%,=""><500 nm="">
- In Vivo：
- GDC-0980 (1 mg/kg, p.o.) demonstrats significant efficacy in mouse xenografts and is currently in phase I clinical trials for cancer. Clearance and PPB are low, and GDC-0980 shows dose-proportional exposure from 5 mg/kg dosed in PEG to 50 mg/kg dosed in suspension in MCT, a finding attributed partially to the compound’s good solubility[1]. GDC-0980 (5 mg/kg, p.o.) results in greater than 50% TGI in 15 of the 20 xenograft models. The difference in tumor response to GDC-0980 treatment correlates with the duration of knockdown of pAkt/tAkt[2].
- Fields：
- GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with Ki of 17 nM, and highly selective versus others PIKK family kinases.
- Specificity：
- Target:PI3K . Fields: GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with Ki of 17 nM, and highly selec
- Source：
- Rabbit
- Dilution：
- IC50: 5 nM (PI3Kα), 27 nM (PI3Kβ), 7 nM (PI3Kδ), 14 nM (PI3Kγ)
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- GDC-0980; RG7422; RG-7422; GDC 0980; GNE 390.
- MolecularWeight(Da)：
- 498.6
- References：
- [1]. Sutherlin DP, et al. Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the
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