Immunoway/3-Methyladenine/50mg 100mg/MC0456
市场价：
¥2000.00
美元价：
1000.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
3-Methyladenine
- Catalog No.：MC0456
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 5142-23-4
- MolecularFormula：
- C6H7N5
- Purity：
- >98%
- Target：
- PI3K
- IC50：
- IC50: 25 μM (Vps34), 60 μM (PI3Kγ)
- In Vitro：
- 3-methyladenine shows some limited Vps34 preference in vitro, with an IC50 of 25 µM for Vps34 as compared with 60 µM for PtdIns3Kγ, and 3-methyladenine (10 mM) can inhibit all PtdIns3Ks[1]. 3-methyladenine (3-MA, 5 mM) suppresses autophagy in HeLa cells under both glucose-free conditions and normal conditions. 3-methyladenine induces caspase-dependent cell death in HeLa cells, and the death occurs independently of the inhibition of autophagy. 3-MA (1 mM) significantly shortens the duration of nocodazole-induced-prometaphase arrest[2]. A large number of neurons from the 3-MA group are in the early stage of apoptosis, displaying cell shrinkage, nuclear and chromatin condensation and aggregation at the edge of the nucleus[3].
- In Vivo：
- 3-methyladenine-treatment significantly aggravates neurological symptoms and apoptotic cell death after SAH[3].
- Fields：
- 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM.
- Specificity：
- Target:PI3K. Fields: 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM.
- Source：
- Rabbit
- Dilution：
- IC50: 25 μM (Vps34), 60 μM (PI3Kγ)
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- 3-MA
- MolecularWeight(Da)：
- 149.15
- References：
- [1]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-807.[2]. Hou H, et al. Inhibitors of phosphatidylinositol 3"-kinases pr
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