Immunoway/AM-2394/10mg 50mg 100mg/MC1237
市场价：
¥6400.00
美元价：
3200.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AM-2394
- Catalog No.：MC1237
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 1442684-77-6
- MolecularFormula：
- C22H25N5O4
- Purity：
- >98%
- Target：
- Glucokinase
- IC50：
- EC50: 60 nM (glucokinase)[1]
- In Vitro：
- In Vivo：
- AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models[1].
- Fields：
- AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. EC50: 60 nM (glucokinase)[1]
- Specificity：
- Target:Glucokinase. Fields: AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. EC50: 60 nM (glucokinase)[1]
- Source：
- Rabbit
- Dilution：
- EC50: 60 nM (glucokinase)[1]
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- AM2394,AM 2394
- MolecularWeight(Da)：
- 423.19
- References：
- [1]. Dransfield PJ, et al. Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett. 2016 May 23;7(7):714-8.
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\Elisa试剂盒\
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