Immunoway/AGI-6780/10mg 50mg 100mg/MC0364
市场价：
¥6000.00
美元价：
3000.00
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3392242852
电话号码：
4000-520-616
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info@ebiomall.com
商品介绍
AGI-6780
- Catalog No.：MC0364
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 1432660-47-3
- MolecularFormula：
- C21H18F3N3O3S
- Purity：
- >98%
- Target：
- Isocitrate Dehydrogenase (IDH)
- IC50：
- IC50: 23±1.7 nM (IDH2R140Q), 190±8.1 nM (IDH2WT)[1]
- In Vitro：
- AGI-6780 is tested in both human glioblastoma U87 and TF-1 cells expressing IDH2R140Q, as well as against IDH1R132H for 48 h incubation, with IC50 of 11±2.6 nM, 18±0.51 nM, and >1 mM, respectivly.Treatment of TF-1R140Q cells with AGI-6780, at concentrations that lower 2HG to near-normal physiologic levels, restore expression of both HBG and KLF1 genes and the color change associated with differentiation. AGI-6780 can reverse the IDH2R140Q-induced differentiation block in TF-1 cells. Pretreatment with AGI-6780 (0.2 μM and 1 μM) markedly decreased the intracellular concentration of (R)-2-hydroxyglutarate in the TF1R140Q cells and restored their ability to undergo EPO-induced differentiation[1].
- In Vivo：
- Fields：
- AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2-R140Q (IC50=23 nM).
- Specificity：
- Target:Isocitrate Dehydrogenase (IDH). Fields: AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dim
- Source：
- Rabbit
- Dilution：
- IC50: 23±1.7 nM (IDH2R140Q), 190±8.1 nM (IDH2WT)[1]
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- AGI 6780; AGI6780
- MolecularWeight(Da)：
- 481.5
- References：
- [1]. Wang F, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013 May 3;340(6132):622-6.
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