Immunoway/(+)MK-801 maleate/10mg 50mg 100mg/MC0730
市场价：
¥2000.00
美元价：
1000.00
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3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
(+)MK-801 maleate
- Catalog No.：MC0730
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 77086-22-7
- MolecularFormula：
- C20H19NO4
- Purity：
- >98%
- Target：
- iGluR
- IC50：
- Ki: 30.5 nM
- In Vitro：
- [3H]MK-801 labels high-affinity binding sites in rat cerebral cortical membranes in a saturable manner. MK-801 produces a potent blockade of depolarizing responses to NMDA in rat cerebral cortical slices. The only compounds that are able to compete for [3H]MK-801 binding sites are substances known to block the responses of excitatory amino acids mediated by the NMDA receptor subtype[1]. MK-801 inhibits N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release and [3H]TCP binding in the hippocampus with IC50 of 20 nM and 9 nM, respectively[2]. MK-801 causes a progressive, long-lasting blockade of current induced by NMDA. Mg2+ (10 mM) prevents MK-801 from blocking the N-Me-D-Asp-induced current, even when MK-801 is applied for a long time in the presence of NMDA. MK-801 is also effective at blocking NMDA-activated single-channel activity in outside-out patches[3]. MK-801 (< 500="" μm)="" prevents="" lps-induced="" activation="" of="" microglia="" in="" a="" concentration-dependent="" manner="" with="" increased="" cox-2="">
- In Vivo：
- Treatment of mice with MK-801 (1 mg/kg) before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. MK-801 (1 mg/kg) attenuates the effects of METH on microglial activation in striatal of mice[4]. MK-801 (0.05 mg/kg or 0.2 mg/kg, i.p.) in rats just prior to reactivation of the cocaine-associated memory in the CPP context attenuates subsequent cocaine-primed reinstatement, while no disruption occurres in rats that do not receive reactivation in the CPP context. MK-801 (0.2 mg/kg, i.p.) prior to two reactivation sessions in the home cage does not suppress subsequent cocaine-primed reinstatement[5].
- Fields：
- Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM Ki: 30.5 nM
- Specificity：
- Target: iGluR . Fields: Dizocilpine maleate(MK 801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM Ki: 30.5 nM
- Source：
- Rabbit
- Dilution：
- Ki: 30.5 nM
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- MK 801 ，MK801
- MolecularWeight(Da)：
- 337.37
- References：
- [1]. Wong EH, et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.[2]. Snell LD, et al. Comparison of the effects of MK-801
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