Immunoway/AZD6244 (Selumetinib,ARRY-142886)/50mg 100mg/MC0175
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¥2400.00
美元价：
1200.00
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3392242852
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4000-520-616
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商品介绍
AZD6244 (Selumetinib,ARRY-142886)
- Catalog No.：MC0175
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 606143-52-6
- MolecularFormula：
- C17H15BrClFN4O3
- Purity：
- >98%
- Target：
- MEK
- IC50：
- IC50: 14 nM (MEK1)
- In Vitro：
- Selumetinib causes a time- and dose-dependent reduction in DNA synthesis and cell viability in primary, induces growth arrest and apoptosis associated with the inactivation of ERK in primary 2-1318 cells[1]. Selumetinib (1µM) shows anti-proliferative effects through G0/G1 arrest on H-441, H-1437 cells[2]. Selumetinib (ARRY-142886) results in the growth inhibition of several cell lines containing B-Raf and Ras mutations but has no effect on a normal fibroblast cell line[3].
- In Vivo：
- Selumetinib (AZD6244, 50 and 100 mg/kg, p.o.) decreases the growth rate of 4-1318 xenografts in a dose-dependent manner; AZD6244 when given at the dose of 50 mg/kg also significantly suppresses the growth of the 5-1318, 2-1318, 26-1004, and 29-1104 xenografts[1]. Selumetinib (ARRY-142886, 10, 25, 50, or 100 mg/kg, p.o.) is capable of inhibiting both ERK1/2 phosphorylation and growth of HT-29 xenograft tumors in nude mice. Tumor regressions are also seen in a BxPC3 xenograft model[3].
- Fields：
- AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.
- Specificity：
- Target:MEK. Fields: AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.
- Source：
- Rabbit
- Dilution：
- IC50: 14 nM (MEK1)
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- ARRY-142886, Selumetinib,AZD-6244,ARRY142886
- MolecularWeight(Da)：
- 457.68
- References：
- [1]. Huynh H, et al, Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Therapy, 2007,
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