Immunoway/AdipoRon/10mg 50mg 100mg/MC0297
市场价：
¥2400.00
美元价：
1200.00
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3392242852
电话号码：
4000-520-616
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info@ebiomall.com
商品介绍
AdipoRon
- Catalog No.：MC0297
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 924416-43-3
- MolecularFormula：
- C27H28N2O3
- Purity：
- >98%
- Target：
- Adiponectin Receptor
- IC50：
- Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
- In Vitro：
- AdipoRon (50 μM) attenuates the expression of TNF-α and TGF-β1, apparently in a dose-dependent manner in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages[1]. AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis[2]. AdipoRon exerts vasodilation by mechanisms distinct to adiponectin. AdipoRon induces vasorelaxation without a marked decrease in VSMC [Ca2+]i[3].
- In Vivo：
- AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice. AdipoRon dose-dependently prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg)[1]. Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice[2].
- Fields：
- AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
- Specificity：
- Target:Adiponectin Receptor. Fields: AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
- Source：
- Rabbit
- Dilution：
- Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- MolecularWeight(Da)：
- 428.52
- References：
- [1]. Wang Y, et al. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Eur J Pharm Sci. 2016 Aug 9;93:123-131.[2]. Zhang Y, et al. AdipoRon, the first orally a
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