免疫法/FK-506（他克莫司）/50mg 100mg/MC0190
市场价：
¥2800.00
美元价：
1400.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
FK-506 (Tacrolimus)
- Catalog No.：MC0190
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 104987-11-3
- MolecularFormula：
- C44H69NO12
- Purity：
- 99%
- Target：
- Autophagy
- IC50：
- No data
- In Vitro：
- Tacrolimus (FK506) inhibits calcium-dependent events, such as IL-2 gene transcription, NO synthase activation, cell degranulation, and apoptosis. Tacrolimus also potentiates the actions of glucocorticoids and progesterone by binding to FKBPs contained within the hormone receptor complex, preventing degradation. The agent may enhance expression of the TGFβ-1 gene in a fashion analogous to that demonstrated for CsA. T cell proliferation in response to ligation of the T cell receptor is inhibited by Tacrolimus[1]. Tacrolimus (FK506) is a powerful immunosuppressive drug widely used to prevent organ rejection after transplantation. Tacrolimus inhibit other calcineurin-dependent transcription factors including the ubiquitously expressed cAMP response element-binding protein (CREB). Tacrolimus inhibit CREB transcriptional activity at the coactivator level. The depolarization-induced transcriptional activity of the CBP C-terminus is enhanced by overexpression of calcineurin and is inhibited by
- In Vivo：
- In the pleurisy induced by carrageenan, Tacrolimus (1 mg/kg, i.p.) and Dexamethasone (0.5 mg/kg, i.p.) administered 0.5 h before causes a significant decrease in leukocytes, neutrophils and exudation (P<0.01). under="" the="" same="" conditions,="" tacrolimus="" and="" dexamethasone="" do="" not="" modify="" the="" blood"s="" white="" or="" red="" cells="" (p="">0.05). Tacrolimus shows a long lasting antiinflammatory effect, inhibiting leukocytes and neutrophils for up to 24 h (P<0.01), whereas="" the="" inhibition="" of="" exudation="" is="" less="" marked="" (up="" to="" 2="" h)=""><0.01). these="" drugs="" caused="" a="" marked="" reduction="" in="" mpo="" activity,="" as="" well="" as="" il-1β="" and="" tnfα="" levels=""><0.01), but="" only="" tacrolimus="" inhibits="" ada="" activity=""><0.01). tacrolimus="" significantly="" inhibits="" cell="" migration="" induces="" by="" either="" bradykinin,="" histamine="" or="" substance="" p=""><>
- Fields：
- An immunosuppressive agent and macrolide antibiotic.
- Specificity：
- Target:Autophagy. Fields: An immunosuppressive agent and macrolide antibiotic.
- Source：
- Rabbit
- Dilution：
- WB 1:500-2000
- Concentration：
- 99%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- Fujimycin,Prograf,FK506,TACROLIMUS
- MolecularWeight(Da)：
- 804.02
- References：
- [1]. Thomson AW, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91.[2]. Vogel KR, et al. mTOR inhibitors rescue premature lethalit
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