Immunoway/ABT-263 (Navitoclax)/10mg 50mg 100mg/MC0153
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¥3200.00
美元价：
1600.00
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3392242852
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4000-520-616
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商品介绍
ABT-263 (Navitoclax)
- Catalog No.：MC0153
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 923564-51-6
- MolecularFormula：
- C47H55ClF3N5O6S3
- Purity：
- 99%
- Target：
- Bcl-2 Family
- IC50：
- Ki: < 1="" nm="" (bcl-xl),="">< 1="" nm="" (bcl-2),="">< 1="" nm="">
- In Vitro：
- Navitoclax (ABT-263) is active against approximately one-half of the cell lines of the PPTP in vitro panel. The median IC50 for all of the lines in the panel is 1.91 µM[1]. Navitoclax in combination with chemotherapy agents leads most ovarian cancer cell lines a synergistic response, and enhances the caspase activation at all paclitaxel doses tested in both SK-OV-3 and IGROV-1 cell lines[2].
- In Vivo：
- Navitoclax (100 mg/kg/day, p.o.) also improves responses to bendamustine-rituximab (BR) in a subset of tumours in mice xenograft[3].
- Fields：
- ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively. Ki: < 1="" nm="" (bcl-xl),="">< 1="" nm="" (bcl-2),="">< 1="" nm="">
- Specificity：
- Target:Bcl-2 Family. Fields: ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively. Ki: < 1="" nm="" (bcl-xl),="">< 1="" nm="" (bcl-2),="">< 1="" nm="">
- Source：
- Rabbit
- Dilution：
- Ki: < 1="" nm="" (bcl-xl),="">< 1="" nm="" (bcl-2),="">< 1="" nm="">
- Concentration：
- 99%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- ABT263,ABT-263
- MolecularWeight(Da)：
- 974.61
- References：
- [1]. Lock R1, et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50(6):1181-1189.[2]. Wong M, et al. Navitoclax (
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