免疫法/ABR-215062（拉奎尼莫）/10mg 50mg 100mg/MC0022
市场价：
¥3200.00
美元价：
1600.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ABR-215062 (Laquinimod)
- Catalog No.：MC0022
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 248281-84-7
- MolecularFormula：
- C19H17ClN2O3
- Purity：
- 99%
- Target：
- Caspase
- IC50：
- No data
- In Vitro：
- Laquinimod reverses EAE and inhibits pathogenic T cell immune responses. Laquinimod reverses RR-EAE and inhibits inflammatory T cell responses via a direct effect on myeloid APC. Laquinimod alters myeloid APC subsets and inhibits Th1 and Th17 polarization of myelin-specific T cells. Laquinimod-induced type II (M2) monocytes reverse established EAE[1]. Laquinimod modulates the phenotype of B cells of healthy donors. Laquinimod modulates expression of markers related to regulatory capacity in B cells of RRMS patients. Laquinimod reduces IFNγ cytokine expression in CD4+ T cells[2].
- In Vivo：
- Laquinimod treatment inhibits donor myelin-specific T cells from transferring EAE to naive recipient mice. In vivo laquinimod treatment alters subpopulations of myeloid antigen presenting cells (APC) that include a decrease in CD11c+CD11b+CD4+ dendritic cells (DC) and an elevation of CD11bhiGr1hi monocytes[1].
- Fields：
- Laquinimod (ABR-215062) is a potent immunomodulator.
- Specificity：
- Target:Caspase. Fields: Laquinimod (ABR-215062) is a potent immunomodulator.
- Source：
- Rabbit
- Dilution：
- WB 1:500-2000
- Concentration：
- 99%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- ABR215062, ABR 215062 (Laquinimod)
- MolecularWeight(Da)：
- 356.8
- References：
- [1]. Schulze-Topphoff, Ulf., et al. Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity. PLoS One (2012), 7(3), e33797.[2]. Toubi E,
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