Immunoway/A-1210477/10mg 50mg 100mg/MC0951
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¥6800.00
美元价：
3400.00
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3392242852
电话号码：
4000-520-616
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info@ebiomall.com
商品介绍
A-1210477
- Catalog No.：MC0951
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 1668553-26-1
- MolecularFormula：
- C46H55N7O7S
- Purity：
- >98%
- Target：
- Bcl-2 Family
- IC50：
- Ki: 0.45 nM (MCL-1), 132 nM (BCL-2), >660 nM (BCL-XL)[1]
- In Vitro：
- A-1210477 (10 μM) reduces the amount of BIM co-immunoprecipitated with MCL-1 antibody, and triggers MCL-1 elevation in a variety of cancer cell lines, including the breast cancer cell line HCC-1806. A-1210477 inhibits MCL-1-NOXA interactions with an IC50 of approximately 1 μM, while having no effect on BCL-2-BIM or BCL-XL-BCL-XS interactions. The NSCLC cell lines H2110 and H23 are sensitive to A-1210477 with cell viability IC50<10 μm, confirming="" that="" a-1210477="" can="" kill="" mcl-1-dependent="" cell="" lines[1].="" a-1210477="" induces="" extensive="" concentration-dependent="" apoptosis="" in="" h929="" cells="" following="" a="" brief="" (4 h)="" exposure.="" a-1210477="" interacts="" with="" mcl-1="" with="" kd="" of="" appr="" 740 nm.="" a-1210477="" (10 μm)="" induces="" extensive="" mitochondrial="" fragmentation="" in="" a="" drp-1-dependent="" manner[2].="" a-1210477="" upregulates="" mcl-1="" expression="" in="" braf-mutant="" crc="" cells="" and="" in="" the="" melanoma="" cell="" line="" a375="" in="" a="" dose-dependent="" manner.="" a-1210477="" releases="" bak="" from="" mcl-1="" and="" cobimetinib="" induces="" bim="" that="" is="" required="" for="" bax="" activation[3].="">
- Fields：
- A-1210477 is a potent and selective MCL-1 inhibitor. Ki: 0.45 nM (MCL-1), 132 nM (BCL-2), >660 nM (BCL-XL)[1]
- Specificity：
- Target: Bcl-2 Family . Fields: A-1210477 is a potent and selective MCL-1 inhibitor. Ki: 0.45 nM (MCL-1), 132 nM (BCL-2), >660 nM (BCL-XL)[1]
- Source：
- Rabbit
- Dilution：
- Ki: 0.45 nM (MCL-1), 132 nM (BCL-2), >660 nM (BCL-XL)[1]
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- A-1210477,A 1210477,A1210477
- MolecularWeight(Da)：
- 850.04
- References：
- [1]. Leverson JD, et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Dea
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品牌分类
\Elisa试剂盒\
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