免疫法/ABT-333/10mg 50mg 100mg/MC0458
市场价：
¥7200.00
美元价：
3600.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ABT-333
- Catalog No.：MC0458
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 1132935-63-7
- MolecularFormula：
- C26H27N3O5S
- Purity：
- >98%
- Target：
- HCV
- IC50：
- IC50: 2.2-10.7 nM (NS5B polymerase)[1]
- In Vitro：
- ABT-333 (Dasabuvir) is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases. ABT-333 (Dasabuvir) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM. ABT-333 inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively[1].
- In Vivo：
- Fields：
- ABT-333 is an NS5B non-nucleoside polymerase inhibitor. IC50: 2.2-10.7 nM (NS5B polymerase)[1]
- Specificity：
- Target:HCV. Fields: ABT-333 is an NS5B non-nucleoside polymerase inhibitor. IC50: 2.2-10.7 nM (NS5B polymerase)[1]
- Source：
- Rabbit
- Dilution：
- IC50: 2.2-10.7 nM (NS5B polymerase)[1]
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- ABT333; ABT 333
- MolecularWeight(Da)：
- 493.57
- References：
- [1]. Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.
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- WESTERN IMMUNOBLOTTING PROTOCOL
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- September 08-2020
- FLOW-CYTOMEYRT-PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
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品牌介绍
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