• Gene Name：
• CDH18

• Protein Name：
• Cadherin-18

• Human Gene Id：
• 1016

• Human Swiss Prot No：
• Q13634

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CDH18. AA range:101-150

• Specificity：
• Cadherin-18 Polyclonal Antibody detects endogenous levels of Cadherin-18 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Rabbit

• Dilution：
• Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -20°C/1 year

• Other Name：
• CDH18; CDH14; Cadherin-18; Cadherin-14

• MolecularWeight(Da)：
• 88073

• Observed Band(KD)：
• 88

• Background：
• cadherin 18(CDH18)Homo sapiensThis gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014],

• Function：
• function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,

• Subcellular Location：
• plasma membrane,integral component of membrane,

• Expression：
• Brain,Cerebellum,

Wu, Jie, et al. "PARP inhibitor re‑sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis." Molecular medicine reports 19.1 (2019): 75-84.

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