免疫法/LY2157299/10mg 50mg 100mg/MC0277
市场价：
¥5400.00
美元价：
2700.00
产品分类：
WB试剂盒
公司分类：
Westornblot
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
LY2157299
- Catalog No.：MC0277
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 700874-72-2
- MolecularFormula：
- C22H19N5O
- Purity：
- >98%
- Target：
- TGF-β Receptor
- IC50：
- IC50: 56 nM (TGF-βR)[1]
- In Vitro：
- LY2157299 (Galunisertib) is a selective ATP-mimetic inhibitor of TGF-β receptor (TβR)-I activation LY2157299 (0.1, 1, 10, and 100 μM) displays a slight dose-dependent potentiation of Sorafenib in SK-Sora, HepG2, and Hep3B cell lines but not in JHH6, SK-HEP1, and HuH7 cell lines[2].
- In Vivo：
- Human xenografts Calu6 (non-small cell lung cancer) and MX1 (breast cancer) are implanted subcutaneously in nude mice. After oral administration of 75 mg/kg, LY2157299 (Galunisertib) induces a 70% decrease in pSmad for both types of cell lines. The time at which pSmad recovered 80% of baseline is approximately 6 h after administration[3].
- Fields：
- LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.
- Specificity：
- Target:TGF-β Receptor. Fields: LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.
- Source：
- Rabbit
- Dilution：
- IC50: 56 nM (TGF-βR)[1]
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C powder,2 weeks 4°C in DMSO,6 months -80°C in DMSO
- Other Name：
- LY-2157299,LY 2157299
- MolecularWeight(Da)：
- 369.42
- References：
- [1]. Cong L, et al. Targeting the TGF-β receptor with kinase inhibitors for scleroderma therapy. Arch Pharm (Weinheim). 2014 Sep;347(9):609-15.[2]. Serova M, et al. Effects of TGF-beta signalling inh
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品牌介绍
ImmunowayImmunoWay Biotechnology，我们的使命是帮助世界各地的生命科学研究人员通过更好的产品和服务简化和加速他们的研究。我们专注于开发用于免疫学和细胞学检测的创新和可靠的产品。我们一直是开发高质量ELISA试剂盒，代谢检测试剂盒，抗体和抗体/蛋白质微阵列的先驱，参与癌症，细胞凋亡，细胞生长和信号转导。ImmunoWay Biotechnology，我们的使命是通过更好的产品和服务帮助世界各地的生命科学研究者简化和加速他们的研究。我们专注于开发创新和可靠的产品，用于免疫学和细胞学检测。我们一直是开发涉及癌症，细胞凋亡，细胞生长和信号转导的高质量ELISA试剂盒，代谢测定试剂盒，抗体和抗体/蛋白质微阵列的先驱。
品牌分类
\Elisa试剂盒\
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