Immunoway/GW788388/10mg 50mg 100mg/MC0353
市场价：
¥3600.00
美元价：
1800.00
产品分类：
标记试剂盒
公司分类：
Labeling_Kit
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
GW788388
- Catalog No.：MC0353
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 452342-67-5
- MolecularFormula：
- C25H23N5O2
- Purity：
- >98%
- Target：
- TGF-β Receptor
- IC50：
- IC50: 18 nM (ALK5)
- In Vivo：
- GW788388 given orally for 5 weeks significantly reduces renal fibrosis and decreased the mRNA levels of key mediators of extracellular matrix deposition in kidneys in db/db mice[1]. GW788388 (50 mg/kg/day, p.o.) significantly attenuates systolic dysfunction in the MI animals, together with the attenuation of the activated (phosphorylated) Smad2 (P < 0.01),="" α-smooth="" muscle="" actin="" (p="">< 0.001),="" and="" collagen="" i="" (p="">< 0.05)="" in="" the="" noninfarct="" zone="" of="" mi="" rats[2].="" gw788388="" reduces="" the="" expression="" of="" collagen="" ia1="" by="" 80%="" at="" a="" dose="" of="" 1="" mg/kg="" twice="" a="" day="" (b.i.d.).="" gw788388="" significantly="" reduces="" the="" expression="" of="" collagen="" ia1="" mrna="" when="" administered="" orally="" at="" 10="" mg/kg="" once="" a="" day="" (u.i.d.)="" in="" a="" model="" of="" puromycin="" aminonucleoside-induced="" renal="">
- Fields：
- GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
- Specificity：
- Target:TGF-β Receptor. Fields: GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inh
- Source：
- Rabbit
- Dilution：
- IC50: 18 nM (ALK5)
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- GW 788388,GW-788388
- MolecularWeight(Da)：
- 425.48
- References：
- [1]. Petersen M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int, 2008, 73(6), 705-715.[2]. Tan SM, et al. Target
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- Products Images
品牌介绍
ImmunowayImmunoWay Biotechnology，我们的使命是帮助世界各地的生命科学研究人员通过更好的产品和服务简化和加速他们的研究。我们专注于开发用于免疫学和细胞学检测的创新和可靠的产品。我们一直是开发高质量ELISA试剂盒，代谢检测试剂盒，抗体和抗体/蛋白质微阵列的先驱，参与癌症，细胞凋亡，细胞生长和信号转导。ImmunoWay Biotechnology，我们的使命是通过更好的产品和服务帮助世界各地的生命科学研究者简化和加速他们的研究。我们专注于开发创新和可靠的产品，用于免疫学和细胞学检测。我们一直是开发涉及癌症，细胞凋亡，细胞生长和信号转导的高质量ELISA试剂盒，代谢测定试剂盒，抗体和抗体/蛋白质微阵列的先驱。
品牌分类
\Elisa试剂盒\
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