Immunoway/KN-93（游离碱）/10mg 50mg 100mg/MC0957
市场价：
¥6000.00
美元价：
3000.00
产品分类：
组织标本
公司分类：
Tissue_samples
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
KN-93(free base)
- Catalog No.：MC0957
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 139298-40-1
- MolecularFormula：
- C26H29ClN2O4S
- Purity：
- >98%
- Target：
- CaMK
- IC50：
- Ki: 370 nM (CaMK)
- In Vitro：
- After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, epidermal growth factor, and insulin-like growth factor-1 in NIH 3T3 fibroblasts[1]. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space[2]. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93[3]. KN-93 (10 μM )significantly inhibits the activation of CaMKII/NF-κB signaling induced by elevated glucose, and subsequently decreases the expression of VEGF, iNOS and ICAM-1 in Müller cells[4].
- In Vivo：
- KN-93 (1 mg/kg/day, i.p.) inhibits retinal vascular leakage induced by diabetes, and suppresses phosphorylation of CaMKII and NF-κB in diabetic retina[4].
- Fields：
- Potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM).
- Specificity：
- Target: CaMK . Fields: Potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM).
- Source：
- Rabbit
- Dilution：
- Ki: 370 nM (CaMK)
- Concentration：
- >98%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- KN-93，KN93,KN 93
- MolecularWeight(Da)：
- 501.04
- References：
- [1]. Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.
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