Immunoway/Lifitegrast（SAR 1118）/10mg 50mg 100mg/MC0839
市场价：
¥6000.00
美元价：
3000.00
产品分类：
WB试剂盒
公司分类：
Westornblot
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Lifitegrast(SAR 1118)
- Catalog No.：MC0839
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 1025967-78-5
- MolecularFormula：
- C29H24CL2N2O7S
- Purity：
- >97%
- Target：
- Integrin
- IC50：
- IC50: 2.98 nM (LFA-1)[1]
- In Vitro：
- Lifitegrast is a novel small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM[1].
- In Vivo：
- Lifitegrast, has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Topical application of lifitegrast to the corneal surface of healthy adults is safe and well tolerated[2]. SAR 1118 ophthalmic drops administered thrice daily deliver therapeutic levels of SAR 1118 in the retina and can alleviate the retinal complications associated with diabetes[3].
- Fields：
- SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye. IC50: 2.98 nM (LFA-1)[1]
- Specificity：
- Target: Integrin . Fields: SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye. IC50: 2.98 nM (LFA-1)[1]
- Source：
- Rabbit
- Dilution：
- IC50: 2.98 nM (LFA-1)[1]
- Concentration：
- >97%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- SAR-1118,SAR1118
- MolecularWeight(Da)：
- 615.49
- References：
- [1]. Perez VL, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14(2):207-15. [2]. Sun Y, et al. Corneal inflammation is inhibited by the LFA-1 a
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品牌介绍
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\Elisa试剂盒\
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