免疫法/VcMMAE/10mg 50mg 100mg/MC0559
市场价：
¥32400.00
美元价：
16200.00
产品分类：
靶向测序试剂盒
公司分类：
Targeted_sequencing_kit
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
VcMMAE
- Catalog No.：MC0559
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- CasNo：
- 646502-53-6
- MolecularFormula：
- C68H105N11O15
- Purity：
- 99.11%
- Target：
- Drug-Linker Conjugates for ADC
- IC50：
- No data
- In Vitro：
- Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells[1]. MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells[2].
- In Vivo：
- Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models[2].
- Fields：
- VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
- Specificity：
- Target: Drug-Linker Conjugates for ADC. Fields: VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via th
- Concentration：
- 99.11%
- Storage Stability：
- 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
- Other Name：
- VC-MMAE,Vc MMAE
- MolecularWeight(Da)：
- 1316.63
- References：
- [1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. [2]. Lisa Buckel, et al. Tumor radiosensitization
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品牌介绍
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品牌分类
\Elisa试剂盒\
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